Description

n-Cbz-D-Glutamic Acid α-Benzyl Ester is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and targeted drug conjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-glutamic acid into peptide chains, enabling the study of structure-activity relationships.
• Pharmaceutical Research: Used in the synthesis of potential active pharmaceutical ingredients (APIs), particularly for metabolic and neurological disorders.
• Prodrug Development: The benzyl ester moiety allows for the design of prodrugs with tailored release profiles and improved bioavailability.
• Bioconjugation: Acts as a linker or spacer molecule in the creation of antibody-drug conjugates (ADCs) and other targeted biotherapeutics.
• Chemical Biology Probes: Employed to synthesize labeled or modified peptides for investigating enzyme mechanisms and protein-protein interactions.
• Custom Synthesis Services: Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects.

Basic Information

Product Name	n-Cbz-D-Glutamic Acid α-Benzyl Ester
CAS No.	65706-99-2
Molecular Formula	C₂₀H₂₁NO₆
Molecular Weight	371.39 g/mol
Synonyms	N-Carbobenzoxy-D-glutamic acid α-benzyl ester; D-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 1-(phenylmethyl) ester; Z-D-Glu(OBzl)-OH; Nα-Cbz-D-glutamic acid 1-benzyl ester; (R)-2-((((Benzyloxy)carbonyl)amino)pentanedioic acid 1-benzyl ester; CBZ-D-Glutamic Acid α-Benzyl Ester; N-CBZ-D-Glutamic Acid 1-Benzyl Ester; NSC 334382
EINECS	Contact for details

Quality Control

Our n-Cbz-D-Glutamic Acid α-Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.