Description

(6R)-3-[[(Aminocarbonyl)Oxy]Methyl]-7α-[[Amino(4-Hydroxyphenyl)Acetyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid CAS NO 65701-49-7 is a high-purity, semi-synthetic cephalosporin antibiotic intermediate. This compound is critical for the synthesis of advanced β-lactam antibiotics, offering a key structural moiety for enhanced antimicrobial activity and stability. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of next-generation cephalosporin drugs, where precise chemical structure and purity are paramount for efficacy and regulatory approval.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as a crucial intermediate in the multi-step synthesis of advanced cephalosporin antibiotics.
• Antibacterial Drug Research & Development: Used as a reference standard and building block in medicinal chemistry for developing new antibacterial agents with improved spectra.
• Process Chemistry & Scale-Up: Employed in optimizing and scaling manufacturing processes for β-lactam antibiotics in GMP environments.
• Analytical Standard: Functions as a high-purity certified reference material (CRM) for quality control and assay development in pharmaceutical analysis.
• Biochemical Studies: Utilized in research to study structure-activity relationships (SAR) and the mechanism of action of β-lactam compounds.

Basic Information

Product Name	(6R)-3-[[(Aminocarbonyl)Oxy]Methyl]-7α-[[Amino(4-Hydroxyphenyl)Acetyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	65701-49-7
Molecular Formula	C19H20N4O7S
Molecular Weight	448.45 g/mol
Synonyms	7β-[2-(4-Hydroxyphenyl)glycylamido]-3-[(carbamoyloxy)methyl]-3-cephem-4-carboxylic Acid; Cefamandole Intermediate; Cefamandole Nucleus; (6R,7R)-7-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-[(carbamoyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cefamandole Acid; Cefamandole Free Acid; Mandol Intermediate; L 116,564 (Antibiotic)
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality systems. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and related substances, IR and NMR for structural confirmation, and rigorous tests for residual solvents and heavy metals. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with ICH guidelines and customer-specific requirements for pharmaceutical ingredient manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.