Description

1’,4-Dihydroxy Triazolam is a key pharmaceutical intermediate and metabolite of the benzodiazepine derivative triazolam. This compound is of significant importance for analytical and research purposes, particularly in the fields of forensic science, clinical toxicology, and pharmaceutical development. It is primarily needed by research institutions, analytical laboratories, and pharmaceutical companies engaged in drug metabolism studies, reference standard preparation, and quality control testing of related active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of triazolam and its metabolites in various matrices.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of triazolam.
• Forensic Toxicology: Serves as a critical analytical standard in forensic laboratories for the detection and confirmation of triazolam use in biological samples.
• Clinical Research: Employed in studies monitoring patient compliance, drug interactions, and therapeutic drug monitoring (TDM) programs.
• Impurity Profiling: Used in the development and validation of methods to identify and quantify related substances in triazolam API manufacturing.
• Academic Research: Utilized in universities and research institutes for pharmacological and biochemical studies on benzodiazepine receptors and their effects.

Basic Information

Product Name	1’,4-Dihydroxy Triazolam
CAS No.	65686-12-6
Molecular Formula	C₁₇H₁₂Cl₂N₄O₂
Molecular Weight	375.21 g/mol
Synonyms	1',4-Dihydroxytriazolam; 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-1',4-diol; Triazolam 1',4-Dihydroxy Metabolite; 1',4-Dihydroxy-8-chloro-6-(2-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine; α-Hydroxytriazolam (isomeric mixture reference); Triazolam Metabolite; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1’,4-Dihydroxy Triazolam is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for research and analytical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.