Description

4-Hydroxytriazolam is a key pharmaceutical intermediate and metabolite of the benzodiazepine derivative triazolam. This compound is of significant importance for research and development in analytical chemistry and pharmacology, particularly in metabolic pathway studies and reference standard preparation. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of analytical standards and reagents for use in method development, quality control, and bioanalytical testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of triazolam and its metabolites in various matrices.
• Metabolite Studies: Used in preclinical and clinical research to investigate the pharmacokinetics, metabolism, and excretion profiles of triazolam.
• Analytical Method Development: A critical component for developing and validating HPLC, LC-MS/MS, and GC-MS methods in forensic and clinical toxicology laboratories.
• Impurity Profiling: Employed as a known impurity standard in the quality control of active pharmaceutical ingredients (APIs) to ensure product purity and compliance.
• Biochemical Research: Utilized in studies exploring the structure-activity relationships (SAR) of benzodiazepine derivatives and their interaction with GABA-A receptors.

Basic Information

Product Name	4-Hydroxytriazolam
CAS No.	65686-11-5
Molecular Formula	C17H12Cl2N4O
Molecular Weight	359.21 g/mol
Synonyms	α-Hydroxytriazolam; 1-Methyl-6-(2-chlorophenyl)-8-chloro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol; 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-1,2,4-triazolo[4,3-a][1,4]benzodiazepin-4-ol; Triazolam Metabolite; 4-OH-Triazolam
EINECS	Contact for details

Quality Control

Our 4-Hydroxytriazolam is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and reference standard applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC purity, related substances) are provided and traceable to in-house reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.