Description

(+/-)-Nicotine-D3 Salicylate Salt CAS NO 65636-94-4 is a deuterium-labeled isotopologue of nicotine salicylate, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is critical for use as an internal standard in quantitative analytical methods, ensuring high accuracy and precision in measurement. It is primarily required by analytical laboratories, pharmaceutical researchers, and contract research organizations (CROs) engaged in pharmacokinetic studies, metabolism research, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the accurate quantification of nicotine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioavailability Studies: Used in drug development and clinical trials to study the absorption, distribution, metabolism, and excretion (ADME) of nicotine and related compounds.
• Forensic and Clinical Toxicology: Enables precise measurement of nicotine levels for substance abuse testing, poisoning cases, and compliance monitoring in smoking cessation programs.
• Metabolite Identification and Pathway Research: Aids in tracing metabolic pathways and identifying novel metabolites in biomedical research.
• Quality Control in Pharmaceutical Manufacturing: Serves as a reference standard for assay validation and impurity profiling in the production of nicotine-based therapeutics (e.g., nicotine replacement therapies).
• Environmental and Agricultural Analysis: Can be utilized in research monitoring nicotine alkaloid levels in environmental samples or agricultural products.

Basic Information

Product Name	(+/-)-Nicotine-D3 Salicylate Salt
CAS No.	65636-94-4
Molecular Formula	C17H18D3N2O3
Molecular Weight	304.37 g/mol (approximate)
Synonyms	Nicotine-d3 Salicylate; (±)-Nicotine-2,4,6-d3 Salicylate Salt; 3-[(2S)-1-Methyl-2-pyrrolidinyl-d3]pyridine Salicylate; DL-Nicotine-d3 Salicylate; Nicotine (methyl-d3) Salicylate; 1-Methyl-2-(3-pyridyl)pyrrolidine-d3 Salicylate; Nicotine-d3 2-Hydroxybenzoate; Labeled Nicotine Salicylate Salt
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Nicotine-D3 Salicylate Salt is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical assay and NMR/MS for isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic purity (D-enrichment), and solvent residue data to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.