Description

Proline, 5-(Cyanomethylene)-, Methyl Ester, (Z)- (9Ci) is a specialized proline derivative featuring a cyanomethylene group, which serves as a key synthetic intermediate for constructing complex molecular architectures. This compound matters for its role in facilitating advanced organic synthesis, particularly in the development of peptidomimetics and novel pharmaceutical scaffolds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for lead optimization and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly protease inhibitors and other peptidomimetic therapeutics.
• Agrochemical Research: Used in the development of new active ingredients with potential herbicidal or insecticidal properties.
• Peptide Chemistry: Serves as a modified amino acid derivative for the solid-phase or solution-phase synthesis of constrained peptides.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying enzyme function.
• Fine Chemical Synthesis: Acts as a versatile chiral synthon for the asymmetric synthesis of complex natural products and specialty chemicals.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for methodological development in organic synthesis.

Basic Information

Product Name	Proline, 5-(Cyanomethylene)-, Methyl Ester, (Z)- (9Ci)
CAS No.	65571-75-7
Molecular Formula	C9H12N2O2
Molecular Weight	180.20 g/mol
Synonyms	(Z)-5-(Cyanomethylene)proline methyl ester; Methyl (Z)-5-(cyanomethylene)-L-prolinate; (Z)-Methyl 5-(cyanomethylene)prolinate; 5-(Cyanomethylene)-L-proline methyl ester; L-Proline, 5-(cyanomethylene)-, methyl ester, (Z)-; Proline derivative 65571-75-7; 2-Pyrrolidinecarboxylic acid, 5-(cyanomethylene)-, methyl ester, (5Z)-
EINECS	Contact for details

Quality Control

Our Proline, 5-(Cyanomethylene)-, Methyl Ester, (Z)- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and reliability for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.