Description

Proline, 5-(Cyanomethylene)-, Methyl Ester, (E)- (9Ci) is a high-value, non-proteinogenic proline derivative characterized by its cyano and ester functional groups. This compound serves as a versatile and critical advanced pharmaceutical intermediate and chiral building block for the synthesis of complex bioactive molecules. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular architecture is required. The compound is supplied under stringent quality control to ensure batch-to-batch consistency for demanding synthetic applications.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Peptidomimetics Research: Used in medicinal chemistry to create constrained peptide analogs and probe structure-activity relationships.
• Organocatalyst Development: Serves as a precursor for novel chiral catalysts used in asymmetric synthesis.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals, flavors, and fragrances.
• Academic & R&D: Valuable reagent for synthetic organic chemistry research in university and corporate laboratories.

Basic Information

Item	Detail
Product Name	Proline, 5-(Cyanomethylene)-, Methyl Ester, (E)- (9Ci)
CAS No.	65571-73-5
Molecular Formula	C8H10N2O2
Molecular Weight	166.18 g/mol
Synonyms	(E)-Methyl 2-cyano-3-pyrrolidin-2-ylacrylate; Methyl (2E)-2-cyano-3-(pyrrolidin-2-yl)prop-2-enoate; 5-(Cyanomethylene)proline methyl ester; (E)-5-(Cyanomethylene)proline methyl ester; 2-Pyrrolidineacrylic acid, 2-cyano-, methyl ester, (E)-; Proline, 5-(cyanomethylene)-, methyl ester, (E)-; A key intermediate for peptidomimetics.
EINECS	Contact for details

Quality Control

Every batch of Proline, 5-(Cyanomethylene)-, Methyl Ester, (E)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.