Description

Rac Methadone-D3 Hydrochloride is a deuterated internal standard of the synthetic opioid analgesic, methadone, specifically designed for analytical and research applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses in complex matrices. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations for method development, validation, and quality control testing.

Application

• Internal Standard for LC-MS/MS and GC-MS: Critical for the precise quantification of methadone and its metabolites in pharmacokinetic, bioequivalence, and therapeutic drug monitoring studies.
• Forensic and Clinical Toxicology: Used in the analysis of biological samples (blood, urine, hair) for the confirmation and accurate measurement of methadone levels in drug testing and overdose investigations.
• Pharmaceutical Research & Development: Supports drug metabolism and pharmacokinetics (DMPK) studies, stability testing, and impurity profiling during the development of methadone-based medications.
• Reference Material for Method Validation: Serves as a certified reference material to validate analytical methods according to regulatory guidelines (e.g., FDA, EMA).
• Metabolite Studies: Aids in the identification and quantification of methadone metabolites in in vitro and in vivo research models.

Basic Information

Product Name	Rac Methadone-D3 Hydrochloride
CAS No.	65566-72-5
Molecular Formula	C21H24D3ClNO
Molecular Weight	353.93 g/mol
Synonyms	Racemic Methadone-D3 HCl; (±)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone-D3 Hydrochloride; DL-Methadone-D3 Hydrochloride; Methadone-d3 (phenyl-d3) Hydrochloride; 4,4-Diphenyl-6-(dimethylamino)-3-heptanone-d3 Hydrochloride; (RS)-Methadone-D3 Hydrochloride; Amidon-D3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Rac Methadone-D3 Hydrochloride is manufactured under strict quality control protocols to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), chemical purity, isotopic purity (D-enrichment), and residual solvents. We adhere to cGMP principles for the production of reference standards, ensuring traceability and reliability for your critical research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chemical Purity	≥ 99.0%
Isotopic Purity (D-enrichment)	≥ 99.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.