Description

Anhydrochlortetracycline Hydrochloride is a high-purity chemical reference standard derived from the tetracycline class of antibiotics. This compound is critically important for analytical and quality control laboratories requiring precise calibration and validation of methods. It is primarily used by pharmaceutical manufacturers, contract research organizations (CROs), and regulatory testing facilities. The product serves as a secondary standard for the accurate quantification and identification of related substances in antibiotic formulations and raw materials.

Application

• Pharmaceutical Reference Standard: Used as a secondary standard for the assay and impurity profiling of chlortetracycline and related tetracycline antibiotics in accordance with pharmacopeial methods (e.g., USP, EP).
• Analytical Method Development & Validation: Essential for developing, calibrating, and validating High-Performance Liquid Chromatography (HPLC) and other chromatographic methods in QC laboratories.
• Microbiological Research: Employed in studies investigating the structure-activity relationships, degradation pathways, and metabolic products of tetracycline antibiotics.
• Quality Control Testing: Provides a benchmark for identity, purity, and potency tests for antibiotic active pharmaceutical ingredients (APIs) and finished drug products.
• Regulatory Compliance & Documentation: Supports regulatory submissions and audits by providing traceable and qualified material for testing protocols.

Basic Information

Product Name	Anhydrochlortetracycline Hydrochloride
CAS No.	65490-24-6
Molecular Formula	C22H22ClN2O7 • HCl
Molecular Weight	515.33 g/mol
Synonyms	4-Epianhydrochlortetracycline Hydrochloride; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-; Anhydrochlortetracycline HCl; 4-Epi-anhydrochlortetracycline HCl; ACTC HCl; DAC Standard
EINECS	Contact for details

Quality Control

Our Anhydrochlortetracycline Hydrochloride is manufactured and tested under a strict quality management system. Each batch is analyzed to ensure it meets stringent specifications for use as a secondary standard. Comprehensive testing includes identification, assay, and related substance analysis via chromatographic and spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. The container should be kept tightly sealed immediately after use.

Specification

Item	Specification
Appearance	Yellow to yellowish-brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.