Description

Cefamandole CAS NO 65338-32-1 is a second-generation cephalosporin antibiotic belonging to the cephamycin class. It is valued for its broad-spectrum antibacterial activity, particularly against Gram-positive and some Gram-negative organisms. This compound is a critical intermediate and active pharmaceutical ingredient (API) essential for pharmaceutical manufacturers in the production of injectable antibiotic formulations.

Application

• Pharmaceutical API: Primary use as the active pharmaceutical ingredient in the synthesis of cefamandole sodium for injection.
• Antibiotic Formulations: Manufacture of sterile injectable products for hospital use to treat serious bacterial infections.
• Research & Development: Used in microbiological research and as a reference standard in analytical laboratories.
• Veterinary Medicine: Potential application in developing antibiotic treatments for animal health.
• Intermediate Synthesis: Serves as a key chemical intermediate for further derivatization and synthesis of related cephalosporin compounds.

Basic Information

Product Name	Cefamandole
CAS No.	65338-32-1
Molecular Formula	C18H18N6O5S2
Molecular Weight	462.50 g/mol
Synonyms	Cefamandole; Cephamandole; Cefamandolum; Cefamandole Free Acid; (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Mandol (as the sodium salt); 65338-32-1
EINECS	Contact for details

Quality Control

Our Cefamandole is manufactured under strict quality management systems. It undergoes rigorous analytical testing to meet high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing parameters such as assay, purity, and identification. We support compliance with cGMP (current Good Manufacturing Practice) guidelines and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits
Specific Rotation	Contact for details
pH (in solution)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.