Description

3-o-Methyl-6β-Naltrexol is a high-purity pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is a key metabolite and derivative of naltrexone, playing a crucial role in advanced pharmacological studies and analytical method development. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions focused on neuropharmacology and opioid receptor research. The product is supplied with full analytical documentation to ensure reliability and reproducibility in sensitive applications.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of naltrexone and its metabolites in drug development and bioanalytical studies.
• Metabolite Research: Serves as a critical standard in pharmacokinetic and metabolic pathway studies related to opioid antagonists.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and development of novel therapeutic agents targeting opioid receptors.
• Analytical Method Development: Essential for developing and validating HPLC, LC-MS, and GC-MS methods in forensic and clinical toxicology.
• Biochemical Research: Used in receptor binding assays and studies investigating the mechanisms of opioid antagonism.
• Quality Control: Acts as a system suitability standard and impurity marker in the quality control of naltrexone-based pharmaceuticals.

Basic Information

Product Name	3-o-Methyl-6β-Naltrexol
CAS No.	65150-66-5
Molecular Formula	C21H27NO4
Molecular Weight	357.45 g/mol
Synonyms	6β-Naltrexol 3-Methyl Ether; 3-O-Methyl-6β-naltrexol; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-Methyl Ether; 6β-Naltrexol Methyl Ether; Noroxymorphone 3-Methyl Ether Derivative; 3-Methoxy-6β-naltrexol
EINECS	Contact for details

Quality Control

Our 3-o-Methyl-6β-Naltrexol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by advanced chromatographic techniques. We adhere to relevant industry standards for reference materials, and custom purity grades or specific impurity specifications can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.