Description

1-Palmitoyl-2-(11-(3-Diazirinophenoxy)Undecanoyl)-Sn-Glycero-3-Phosphocholine CAS NO 65114-56-9 is a specialized, photoactivatable phospholipid derivative designed for advanced biochemical and biophysical research. Its core value lies in the diazirine moiety, which enables covalent cross-linking upon UV irradiation, making it an indispensable tool for studying lipid-protein interactions and membrane dynamics. This high-purity compound is essential for researchers and developers in structural biology, proteomics, and drug discovery, particularly for mapping binding sites and understanding complex cellular signaling pathways.

Application

• Membrane Protein Interaction Studies: As a photoaffinity labeling probe to capture and identify transient or weak interactions between membrane proteins and their lipid environment.
• Lipidomics and Proteomics Research: Used to tag and isolate lipid-binding proteins for mass spectrometry analysis, aiding in the discovery of novel drug targets.
• Lipid Bilayer and Liposome Engineering: Incorporation into model membranes (e.g., liposomes, nanodiscs) to study membrane structure, fluidity, and the mechanism of action of membrane-active compounds.
• Drug Discovery Screening: Employed in high-throughput assays to identify and characterize small molecules that interact with specific lipid domains or membrane-bound targets.
• Structural Biology Techniques: A critical reagent for techniques like cryo-electron microscopy (cryo-EM) to stabilize and visualize protein-lipid complexes.
• Cell Signaling Pathway Analysis: To trace and covalently link signaling lipids to their effector proteins within live cells or cellular extracts.

Basic Information

Product Name	1-Palmitoyl-2-(11-(3-Diazirinophenoxy)Undecanoyl)-Sn-Glycero-3-Phosphocholine
CAS No.	65114-56-9
Molecular Formula	C₄₇H₈₄N₃O₉P
Molecular Weight	882.15 g/mol
Synonyms	Photoactivatable PC Lipid; Diazirine-PC; 1-Palmitoyl-2-(11-((3-(trifluoromethyl)-3H-diazirin-3-yl)phenoxy)undecanoyl)-sn-glycero-3-phosphocholine; PtdCho(16:0/Diazirine-PE); Photo-leucine phospholipid analog; Membrane probe lipid; Cross-linking phospholipid; TPD-PC
EINECS	Contact for details

Quality Control

Every batch of our 1-Palmitoyl-2-(11-(3-Diazirinophenoxy)Undecanoyl)-Sn-Glycero-3-Phosphocholine is manufactured under strict quality protocols to ensure the highest standards of purity and functional integrity required for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity confirmation, and stability data. Our quality system is designed to support GMP-grade research and development, ensuring batch-to-batch consistency and reliable performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is strictly light-sensitive and must be handled under subdued light or amber glass to prevent premature activation of the diazirine group. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98%
Solubility	Soluble in chloroform, methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.