Description

Normorphine-6-Glucuronide is a significant glucuronide metabolite of normorphine, a key intermediate in the study of opioid metabolism. This reference standard is essential for analytical research, providing a critical benchmark for the identification and quantification of opioid metabolites in biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, forensic toxicology units, and clinical research organizations engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and substance abuse testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the calibration of analytical instruments and validation of testing methods in drug development.
• Metabolite Identification & Quantification: Critical for DMPK studies to understand the metabolic pathways and clearance rates of opioid compounds.
• Forensic Toxicology: Used as a calibrant and control in liquid chromatography-mass spectrometry (LC-MS/MS) assays for the accurate detection of opioid use in biological samples (e.g., urine, blood).
• Clinical Research: Supports studies investigating opioid metabolism variability, drug-drug interactions, and personalized medicine approaches.
• Bioanalytical Method Development: Essential for developing and optimizing sensitive and specific HPLC or UPLC methods for metabolite analysis.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control laboratories of pharmaceutical manufacturers producing opioid-based medications.

Basic Information

Product Name	Normorphine-6-Glucuronide
CAS No.	65060-95-9
Molecular Formula	C23H27NO9
Molecular Weight	461.46 g/mol
Synonyms	Normorphine 6-β-D-Glucuronide; 6-Glucuronylnormorphine; Normorphine-6-β-D-Glucopyranosiduronic Acid; N-Desmethylmorphine-6-Glucuronide; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 6-Glucuronide; 6-Normorphine Glucuronide; Normorphine Glucuronide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Normorphine-6-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label/COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.