Description

Benzyloxycarbonylproline n-Methylamide is a protected proline derivative, a crucial building block in peptide synthesis and medicinal chemistry. Its primary value lies in enabling the controlled introduction of proline residues while protecting the secondary amine, which is essential for constructing complex peptide architectures. This compound is a key intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostics, and research tools. Its stability and reactivity profile make it indispensable for solid-phase and solution-phase peptide synthesis workflows.

Application

• Peptide Synthesis Intermediate: A fundamental building block (amino acid derivative) for the controlled incorporation of proline in both research-scale and commercial peptide production.
• Pharmaceutical Active Pharmaceutical Ingredient (API) Development: Used in the research and synthesis of novel peptide-based drug candidates targeting various diseases.
• Bioconjugation & Probe Development: Serves as a modified amino acid component for creating labeled peptides used in biochemical assays, imaging, and diagnostic applications.
• Chemical Biology Research: Employed in studying protein-protein interactions, enzyme substrates, and receptor ligands by incorporating modified proline structures.
• Process Chemistry & Scale-Up: Used in the development and optimization of large-scale manufacturing processes for therapeutic peptides.
• Custom Peptide Service Provider: A critical raw material for companies offering bespoke peptide synthesis services to academic and industrial clients.

Basic Information

Product Name	Benzyloxycarbonylproline n-Methylamide
CAS No.	65057-32-1
Molecular Formula	C14H18N2O3
Molecular Weight	262.31 g/mol
Synonyms	Z-Pro-NHMe; Cbz-Pro-NHMe; N-[(Benzyloxy)carbonyl]-L-proline N-methylamide; (S)-1-((Benzyloxy)carbonyl)-N-methylpyrrolidine-2-carboxamide; N-Carbobenzoxy-L-proline N-methylamide; Nα-Cbz-N-methyl-L-prolinamide; N-Cbz-L-proline methylamide; L-Proline, N-[(phenylmethoxy)carbonyl]-, N-methylamide
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonylproline n-Methylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for assay, chiral purity, and related substances is provided with every shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.