Description

(7R)-3-[(5-Methyl-1,3,4-Thiadiazole-2-Yl)Thiomethyl]-7β-[(Z)-(2-Aminothiazole-4-Yl)(Methoxyimino)Acetylamino]Cepham-3-Ene-4-Carboxylic Acid Sodium Salt is a high-purity, semi-synthetic cephalosporin intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of advanced third-generation cephalosporin antibiotics, valued for its role in creating broad-spectrum antibacterial agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of sterile injectable antibiotics.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key intermediate in the industrial-scale production of third-generation cephalosporin antibiotics, such as cefmenoxime and related compounds.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the design, synthesis, and structure-activity relationship (SAR) studies of new β-lactam antibacterial agents.
• Sterile Injectable Formulations: Serves as a precursor in the manufacturing of finished dosage forms for parenteral administration, targeting serious systemic infections.
• Antibiotic Potency & Spectrum Enhancement: The structural features of this intermediate contribute to enhanced stability against β-lactamases and improved activity against Gram-negative bacteria.
• GMP Manufacturing: Supplied as a critical raw material for use in cGMP-compliant production facilities for regulated markets.
• Reference Standard: Can be utilized as a chromatographic reference standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Item	Details
Product Name	(7R)-3-[(5-Methyl-1,3,4-Thiadiazole-2-Yl)Thiomethyl]-7β-[(Z)-(2-Aminothiazole-4-Yl)(Methoxyimino)Acetylamino]Cepham-3-Ene-4-Carboxylic Acid Sodium Salt
CAS No.	65052-72-4
Molecular Formula	C18H18N8O5S3Na
Molecular Weight	569.57 g/mol
Synonyms	Sodium (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Cefmenoxime Intermediate; Cefmenoxime Sodium Salt Intermediate; (6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; SC E 1365 Intermediate; Antibiotic SC E-1365 Intermediate
EINECS	Contact for details

Quality Control

Our (7R)-3-[(5-Methyl-1,3,4-Thiadiazole-2-Yl)Thiomethyl]-7β-[(Z)-(2-Aminothiazole-4-Yl)(Methoxyimino)Acetylamino]Cepham-3-Ene-4-Carboxylic Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent control of related substances and residual solvents to meet pharmaceutical intermediate standards. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment. Recommended long-term storage at controlled room temperature (15-25°C).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.