Description

[6R-(6Alpha,7Beta)]-7-(Aminophenylacetamido)-3-Chloro-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid CAS NO 64753-81-7 is a key advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of specific semi-synthetic β-lactam antibiotics, offering a precise chemical scaffold for further functionalization. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on developing and producing novel or generic antibiotic formulations.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of specific third-generation cephalosporin antibiotics.
• Antibiotic Research & Development: Used in medicinal chemistry programs to develop new analogs with improved efficacy or spectrum of activity against resistant bacteria.
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the production process of finished antibiotic APIs for commercial scale-up.
• Process Chemistry & Optimization: Employed in route scouting and process development to improve the yield and purity of final antibiotic products.
• Reference Standard: Utilized as a high-purity analytical standard for quality control testing of related APIs and finished drug products.

Basic Information

Product Name	[6R-(6Alpha,7Beta)]-7-(Aminophenylacetamido)-3-Chloro-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	64753-81-7
Molecular Formula	C15H14ClN3O4S
Molecular Weight	367.81 g/mol
Synonyms	7-ACA-3-chloro derivative; 3-Chloro-7-ACA; 7-Aminocephalosporanic Acid 3-Chloro Derivative; 3-Chloro-7-ADCA; (6R,7R)-7-Amino-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; 7-[(Aminophenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Cephalosporin C Nucleus 3-Chloro Analog
EINECS	Contact for details

Quality Control

Our [6R-(6Alpha,7Beta)]-7-(Aminophenylacetamido)-3-Chloro-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.