Description

Propantheline-D3 Bromide (n-Methyl-D3) is a deuterium-labeled analog of the anticholinergic agent propantheline bromide, specifically deuterated on the N-methyl group. This stable isotope-labeled compound is an essential internal standard for the precise quantification of propantheline in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical research and development laboratories, clinical research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Primary use as an internal standard for the accurate LC-MS/MS quantification of propantheline in bioanalytical assays.
• Critical component in pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand drug absorption, distribution, metabolism, and excretion.
• Facilitates drug metabolism and disposition (DMPK) research by enabling precise tracking of the parent drug.
• Used in the development and validation of regulatory-compliant bioanalytical methods for clinical trials.
• Supports forensic and toxicological analysis for the detection and quantification of propantheline.
• Essential for isotope dilution mass spectrometry techniques to ensure high accuracy and reproducibility in quantitative analysis.

Basic Information

Product Name	Propantheline-D3 Bromide (n-Methyl-D3)
CAS No.	64717-35-7
Molecular Formula	C23H27D3NO3 • Br
Molecular Weight	~ 448.42 g/mol
Synonyms	Propantheline-d3 Bromide; (2-Hydroxyethyl)diisopropylmethylammonium bromide xanthene-9-carboxylate-d3; Pro-Banthine-d3; Propanthelin-d3 Bromide; N-Methyl-d3 Propantheline Bromide; 9-Carboxy-2-hydroxy-N,N,N-triisopropyl-5-((methyl-d3)amino)-5-oxopentyl)xanthen-9-ium Bromide; Deuterated Propantheline Bromide
EINECS	Contact for details

Quality Control

Our Propantheline-D3 Bromide is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive mass spectrometry applications. Each batch is analyzed to confirm identity, isotopic enrichment (D3, typically >99 atom % D), and chemical purity (typically ≥98% by HPLC). A comprehensive Certificate of Analysis (COA) is provided, detailing all relevant specifications including assay, impurity profile, and residual solvent content, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.