Description

Parathyroid Hormone (24-48) CAS NO 64717-18-6 is a bioactive peptide fragment derived from the human parathyroid hormone, specifically encompassing amino acid residues 24 through 48. This synthetic peptide is a critical research tool for studying calcium and phosphate metabolism, bone biology, and the structure-activity relationships of the full-length hormone. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic disorders and endocrine research.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of parathyroid hormone receptor (PTH1R) binding and signal transduction pathways.
• Drug Discovery: Serves as a key intermediate or pharmacophore model in the development of novel therapeutics for osteoporosis, hypoparathyroidism, and chronic kidney disease-mineral and bone disorder (CKD-MBD).
• In Vitro Assays: Employed in cell-based assays (e.g., cAMP stimulation) to evaluate biological activity and screen for PTH agonists or antagonists.
• Structure-Activity Relationship (SAR) Studies: Essential for mapping the functional domains of parathyroid hormone to understand the contributions of specific amino acid sequences to its biological effects.
• Antibody Production: Can be used as an immunogen to generate specific antibodies for immunoassays and diagnostic research.
• Academic & Clinical Research: Supports fundamental research into calcium homeostasis, bone remodeling, and endocrine physiology.

Basic Information

Product Name	Parathyroid Hormone (24-48)
CAS No.	64717-18-6
Molecular Formula	C₁₁₇H₁₉₀N₃₈O₄₀
Molecular Weight	~2785.0 g/mol
Synonyms	PTH (24-48); Human Parathyroid Hormone (24-48); Parathyrin (24-48); hPTH (24-48); PTH 24-48 fragment; PTH 24-48 peptide; [Tyr34]hPTH(24-48) amide (common research form); Parathyroid hormone fragment 24-48 human
EINECS	Contact for details

Quality Control

Our Parathyroid Hormone (24-48) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.