Description

L-Proline, 4-Hydroxy-, Hydrazide, trans- (9Ci) is a specialized derivative of the amino acid proline, featuring a hydrazide functional group. This unique structure makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for constructing complex molecules with high stereochemical control. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially peptidomimetics and enzyme inhibitors.
• Agrochemical Synthesis: Used in the creation of advanced, biologically active compounds for crop protection products.
• Bioconjugation & Probe Development: The reactive hydrazide group enables site-specific labeling and conjugation in biochemical research and diagnostic assay development.
• Asymmetric Catalysis: Serves as a precursor for ligands or organocatalysts used in stereoselective chemical transformations.
• Peptide Chemistry: Employed in the synthesis of modified peptides and peptide analogs to study structure-activity relationships.
• Academic & Industrial R&D: A fundamental reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	L-Proline, 4-Hydroxy-, Hydrazide, trans- (9Ci)
CAS No.	64616-75-7
Molecular Formula	C6H11N3O3
Molecular Weight	173.17 g/mol
Synonyms	(2S,4R)-4-Hydroxypyrrolidine-2-carbohydrazide; trans-4-Hydroxy-L-proline hydrazide; (4R)-4-Hydroxy-L-proline hydrazide; L-4-Hydroxyproline hydrazide; 4-Hydroxy-L-proline hydrazide; Hydroxyproline hydrazide; (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylic acid hydrazide
EINECS	Contact for details

Quality Control

We maintain a robust quality management system to ensure the integrity of our high-purity intermediates. Each batch of L-Proline, 4-Hydroxy-, Hydrazide, trans- (9Ci) is subjected to rigorous analytical testing, including HPLC for purity and chiral integrity, to meet exacting research and production standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.