Description

Isoguvacine Hydrochloride is a potent and selective GABAA receptor agonist, serving as a crucial research chemical in neuroscience and pharmacology. This compound is valued for its high biological activity and specificity, making it an indispensable tool for studying inhibitory neurotransmission and receptor function. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and neurochemical analysis.

Application

• Neuroscience Research: A key pharmacological tool for investigating GABAA receptor subtypes, function, and distribution in the brain.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for novel CNS therapeutics targeting anxiety, epilepsy, and sleep disorders.
• Biochemical Assays: Serves as a reference standard and active control in receptor binding studies, functional assays, and electrophysiology experiments.
• Academic Studies: Employed in university and institutional research to explore the fundamentals of synaptic transmission and neural circuitry.
• Toxicology & Safety Pharmacology: Used to assess compound effects on GABAergic systems as part of preclinical safety profiles.

Basic Information

Product Name	Isoguvacine Hydrochloride
CAS No.	64603-90-3
Molecular Formula	C6H10ClNO2
Molecular Weight	163.60 g/mol
Synonyms	3-Isoxazoleacetic acid, 4,5-dihydro-5-oxo-, hydrochloride; 4,5-Dihydro-5-oxoisoxazole-3-acetic acid hydrochloride; (RS)-Isoguvacine hydrochloride; (±)-Isoguvacine hydrochloride; Guvacine isomer hydrochloride; GABA agonist isoguvacine HCl
EINECS	Contact for details

Quality Control

Our Isoguvacine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.