Description

(S)-(-)-2-Methoxypropionitrile is a chiral nitrile compound of significant interest in advanced organic synthesis. Its value lies in its utility as a versatile chiral building block for the preparation of enantiomerically pure pharmaceuticals and fine chemicals. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce stereochemical complexity into target molecules.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the production of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the development of cardiovascular and central nervous system drugs.
• Asymmetric Catalyst Ligand Synthesis: Used in the preparation of chiral ligands for transition metal catalysts employed in asymmetric hydrogenation and carbon-carbon bond-forming reactions.
• Agrochemical Intermediate: Serves as a building block for the synthesis of chiral herbicides, fungicides, and plant growth regulators with enhanced biological activity and environmental profile.
• Fine Chemical and Flavor/Fragrance Production: Employed in the synthesis of complex, high-value chiral molecules for flavors, fragrances, and advanced material science applications.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new synthetic routes to complex natural products.

Basic Information

Product Name	(S)-(-)-2-Methoxypropionitrile
CAS No.	64531-49-3
Molecular Formula	C4H7NO
Molecular Weight	85.10 g/mol
Synonyms	(S)-2-Methoxypropionitrile; (S)-(-)-2-Methoxypropane nitrile; (S)-2-Methoxypropanenitrile; (S)-α-Methoxypropionitrile; (S)-2-Methoxypropionic acid nitrile; (S)-O-Methyl lactonitrile; (S)-2-Methoxy-1-cyanoethane
EINECS	Contact for details

Quality Control

Our (S)-(-)-2-Methoxypropionitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, GC for purity, and identity confirmation via FT-IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation [α]D20	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.