Description

Cefotaxime Sodium is a semi-synthetic, broad-spectrum third-generation cephalosporin antibiotic. It is valued for its potent bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria, including many β-lactamase-producing strains. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable antibiotics used in hospital and clinical settings worldwide.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for intravenous or intramuscular administration.
• Hospital Infection Treatment: Formulated for treating serious infections such as septicemia, meningitis, and infections of the lower respiratory tract, urinary tract, bones, and joints.
• Surgical Prophylaxis: Used to prevent post-operative infections in major surgeries.
• Gynecological & Obstetric Infections: Treatment of pelvic inflammatory disease and other gynecological infections.
• Research & Development: Serves as a reference standard and key intermediate in pharmaceutical R&D for novel antibiotic studies.
• Veterinary Medicine: Used in the treatment of bacterial infections in animals, following appropriate regulatory guidelines.

Basic Information

Product Name	Cefotaxime Sodium
CAS No.	64485-93-4
Molecular Formula	C16H16N5NaO7S2
Molecular Weight	477.44 g/mol
Synonyms	Cefotaxime Sodium Salt; (6R,7R)-3-(Acetoxymethyl)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt; Sodium (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Claforan (Brand Name); Cefotax; Zariviz; HR-756
EINECS	264-921-2

Quality Control

Our Cefotaxime Sodium is manufactured and tested under strict quality management systems. It is produced to meet or exceed the standards of major pharmacopoeias, including USP (United States Pharmacopeia) and EP (European Pharmacopoeia). Every batch undergoes comprehensive analytical testing for identity, purity, potency, and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	96.0% - 102.0% (on anhydrous basis)
pH (10% solution)	4.5 - 6.5
Water Content (KF)	≤ 2.0%
Specific Optical Rotation	+58° to +64°
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.