Description

(E)-3-(4-Methoxyphenylsulfonyl)Acrylonitrile is a specialized organic building block featuring a conjugated acrylonitrile system linked to a sulfonyl-activated aromatic ring. This compound matters as a versatile Michael acceptor and electrophilic synthon, enabling the construction of complex molecules through nucleophilic addition and cycloaddition reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly those with sulfonamide or vinyl sulfone pharmacophores.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides that require a sulfonyl acrylonitrile moiety for biological activity.
• Material Science Monomer: Serves as a functional monomer for creating specialty polymers with unique electronic or adhesive properties.
• Organic Synthesis Reagent: Acts as a dienophile in Diels-Alder reactions and an electrophile in Michael addition reactions to form carbon-carbon bonds.
• Chemical Biology Probe: Utilized in designing activity-based probes (ABPs) to study enzyme function due to its reactive double bond.

Basic Information

Product Name	(E)-3-(4-Methoxyphenylsulfonyl)Acrylonitrile
CAS No.	64326-50-7
Molecular Formula	C10H9NO3S
Molecular Weight	223.25 g/mol
Synonyms	trans-3-(4-Methoxyphenylsulfonyl)acrylonitrile; (E)-3-(p-Methoxyphenylsulfonyl)propenenitrile; 4-Methoxyphenyl vinyl sulfone nitrile; 2-Propenenitrile, 3-[(4-methoxyphenyl)sulfonyl]-, (2E)-; p-Methoxyphenylsulfonylacrylonitrile; 4-Methoxybenzenesulfonylacrylonitrile; (E)-3-((4-Methoxyphenyl)sulfonyl)acrylonitrile
EINECS	Contact for details

Quality Control

Our (E)-3-(4-Methoxyphenylsulfonyl)Acrylonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.