Description

Angiotensinogen is a critical plasma protein and the sole precursor to the potent vasoconstrictor peptides of the renin-angiotensin system (RAS). This high-purity biochemical is essential for research and development in cardiovascular physiology and pharmacology. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic researchers studying hypertension, renal function, and related metabolic disorders.

Application

• Biomedical Research: Fundamental studies on the renin-angiotensin system (RAS), blood pressure regulation, and fluid-electrolyte balance.
• Drug Discovery & Development: Serving as a key substrate for screening and characterizing novel renin and ACE (angiotensin-converting enzyme) inhibitors.
• Diagnostic Assay Development: Used as a critical standard or component in immunoassays (ELISA, RIA) for measuring renin activity or angiotensinogen levels in clinical samples.
• Enzyme Kinetics Studies: Investigating the catalytic mechanisms and kinetics of renin and other proteases involved in the RAS cascade.
• Cell Culture & In Vitro Models: Application in cell-based assays to study angiotensin II production and its cellular effects.
• Reference Standard: Acting as a purified protein standard for quality control in related biopharmaceutical processes.

Basic Information

Item	Details
Product Name	Angiotensinogen
CAS No.	64315-16-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Serpin A8; Angiotensin Precursor; Renin Substrate; ANGT; AGT; Serpin Peptidase Inhibitor Clade A Member 8
EINECS	Contact for details

Quality Control

Our Angiotensinogen is produced and tested under stringent quality management systems. Each batch is subjected to comprehensive analytical characterization to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, documenting key parameters such as purity (by SDS-PAGE and HPLC), protein concentration, and functional activity. We adhere to relevant guidelines for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (SDS-PAGE)	> 90%
Purity (HPLC)	> 95%
Protein Content (BCA)	> 90% of stated weight
Biological Activity	Determined by renin cleavage assay
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.