Description

Boc-n-Methyl-Dl-Phenylalanine CAS NO 64263-83-8 is a protected amino acid derivative featuring a tert-butoxycarbonyl (Boc) group on the nitrogen and a methyl group on the α-amino nitrogen. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing modified phenylalanine units while providing orthogonal protection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based therapeutics and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate N-methylated phenylalanine residues, which can enhance metabolic stability and alter conformational properties of peptides.
• Proteomics Research: Serves as a building block for creating custom amino acid analogs in biochemical studies and proteomics research.
• Chemical Biology: Employed in the synthesis of molecular probes and inhibitors to study enzyme function and protein-protein interactions.
• Academic & Industrial R&D: A fundamental reagent in organic chemistry laboratories for methodological development and the synthesis of complex natural products or novel materials.

Basic Information

Product Name	Boc-n-Methyl-Dl-Phenylalanine
CAS No.	64263-83-8
Molecular Formula	C15H21NO4
Molecular Weight	279.33 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N-methyl-DL-phenylalanine; Boc-N-Me-DL-Phe-OH; (RS)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-phenylpropanoic acid; tert-Butyl N-methyl-N-[(RS)-1-carboxy-2-phenylethyl]carbamate; DL-N-Methyl-N-Boc-phenylalanine; Boc-DL-N-methylphenylalanine; N-Boc-N-methyl-DL-phenylalanine; Nα-Boc-Nα-methyl-DL-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-n-Methyl-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.