Description

1,2-Difluoro-4-Iodobenzene is a versatile fluorinated and iodinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This high-purity compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals, where precise functionalization is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoro-iodo motif can impart specific biological activity.
• Liquid Crystal Materials (LCs): Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for OLED devices.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira), enabling rapid diversification of the benzene ring.
• Material Science Research: Used in academic and industrial R&D for creating novel fluorinated polymers and advanced organic materials.

Basic Information

Product Name	1,2-Difluoro-4-Iodobenzene
CAS No.	64248-58-4
Molecular Formula	C6H3F2I
Molecular Weight	239.99 g/mol
Synonyms	4-Iodo-1,2-difluorobenzene; 1,2-Difluoro-4-iodobenzene; 3,4-Difluoroiodobenzene; 4-Iodo-o-difluorobenzene; Benzene, 1,2-difluoro-4-iodo-; I-3,4-Difluorophenyl
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-4-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and meet the stringent requirements of our global clientele in research and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.