Description

4-Fluoro-L-Phenylalanine Methyl Ester, Hcl is a fluorinated amino acid derivative, specifically the methyl ester hydrochloride salt of 4-fluoro-L-phenylalanine. This compound is a crucial chiral building block in organic synthesis, valued for its role in introducing the 4-fluorophenylalanine moiety into more complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, proteomics research, and the synthesis of potential therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in peptide-based drug discovery.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a fluorinated phenylalanine residue, which can alter the biological activity, stability, and metabolic profile of synthetic peptides.
• Proteomics & Biochemical Research: Serves as a precursor for labeled amino acids or as a tool compound in studies of enzyme mechanisms and protein structure-function relationships.
• Agrochemical Research: Potential intermediate in the synthesis of advanced, fluorinated agrochemicals where the fluorine atom can enhance bioactivity and environmental stability.
• Material Science: Can be employed in the synthesis of specialized polymers or dendrimers with unique properties derived from fluorinated aromatic groups.

Basic Information

Product Name	4-Fluoro-L-Phenylalanine Methyl Ester, Hcl
CAS No.	64231-55-6
Molecular Formula	C10H13FNO2 • HCl
Molecular Weight	233.67 g/mol (Free base: 197.22 g/mol)
Synonyms	L-4-Fluorophenylalanine methyl ester hydrochloride; Methyl (2S)-2-amino-3-(4-fluorophenyl)propanoate hydrochloride; (S)-Methyl 2-amino-3-(4-fluorophenyl)propanoate hydrochloride; 4-Fluoro-L-Phe-OMe • HCl; F-Phe-OMe • HCl; p-Fluoro-L-phenylalanine methyl ester hydrochloride; 4-F-Phe-OMe • HCl
EINECS	Contact for details

Quality Control

Our 4-Fluoro-L-Phenylalanine Methyl Ester, Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.