Description

Boc-Leu-Pro-Oh CAS NO 64205-66-9 is a protected dipeptide building block, specifically the tert-butoxycarbonyl (Boc) derivative of the leucine-proline dipeptide with a free carboxylic acid terminus. This compound is a critical intermediate in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptide chains. It is essential for research and development laboratories in the pharmaceutical, biotechnology, and life sciences sectors focused on creating novel therapeutic peptides, peptide hormones, and biochemical probes.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of complex therapeutic peptides and peptidomimetics.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc/t-Boc strategies for the controlled elongation of peptide sequences.
• Biochemical Research: Synthesis of substrates, inhibitors, or standards for enzyme studies (e.g., protease research).
• Combinatorial Chemistry: A valuable component in libraries for drug discovery and high-throughput screening.
• Peptide-Based Drug Development: R&D of novel peptide drugs targeting metabolic disorders, oncology, and infectious diseases.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.

Basic Information

Product Name	Boc-Leu-Pro-Oh
CAS No.	64205-66-9
Molecular Formula	C₁₆H₂₈N₂O₅
Molecular Weight	328.41 g/mol
Synonyms	Boc-Leu-Pro-OH; N-(tert-Butoxycarbonyl)-L-leucyl-L-proline; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanamido)pyrrolidine-1-carboxylic acid; tert-Butoxycarbonyl-L-leucyl-L-proline; Boc-L-Leu-L-Pro-OH; N-Boc-L-leucyl-L-proline; L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-, L-prolyl-; Peptide synthesis intermediate Boc-Leu-Pro
EINECS	Contact for details

Quality Control

Our Boc-Leu-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-70° to -76° (c=1, in AcOH)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.