Description

Diclofenac Acyl Glucuronide is a major Phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) Diclofenac. This compound is of critical importance in pharmaceutical research and development, particularly for metabolism and pharmacokinetic studies. It is primarily needed by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in bioanalytical method development, drug safety assessment, and metabolite reference standard synthesis.

Application

• Pharmaceutical Reference Standard: Serves as a certified high-purity standard for the quantitative and qualitative analysis of Diclofenac metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance mechanisms, and bioavailability of Diclofenac.
• Toxicology and Safety Assessment: Essential for studying the potential role of reactive acyl glucuronides in drug-induced liver injury (DILI) and other idiosyncratic toxicities.
• Bioanalytical Method Development: A key analyte for developing and validating robust LC-MS/MS or HPLC methods for metabolite profiling.
• Clinical Research: Used as a calibrator or control in studies monitoring patient metabolite levels for pharmacokinetic/pharmacodynamic (PK/PD) modeling.
• Impurity Profiling: Acts as a specified impurity reference standard in the quality control of Diclofenac active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Diclofenac Acyl Glucuronide
CAS No.	64118-81-6
Molecular Formula	C21H21Cl2NO9
Molecular Weight	502.30 g/mol
Synonyms	Diclofenac 1-O-Acyl-β-D-Glucuronide; Diclofenac Acyl-β-D-Glucuronide; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid 1-(β-D-glucopyranuronosyl) ester; Diclofenac AG; Diclofenac Acyl Gluc; Diclofenac β-1-O-Acyl Glucuronide; DCF AG
EINECS	Contact for details

Quality Control

Our Diclofenac Acyl Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) with detailed chromatograms and spectral data to ensure traceability and compliance with research-grade standards. Specifications are aligned with the needs of analytical and pharmaceutical development laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.