Description

2-(Trifluoromethoxy)Bromobenzene is a versatile and high-value fluorinated aromatic building block essential for advanced organic synthesis. Its core value lies in the unique combination of a bromo substituent for cross-coupling reactions and a stable trifluoromethoxy group, which imparts desirable properties like enhanced metabolic stability and lipophilicity to target molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the CF3O- group improves biological activity and environmental persistence.
• Material Science Precursors: Serves as a monomer or precursor for specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for Suzuki, Stille, and Negishi couplings to form biaryl structures.
• Functional Group Transformation: Used in lithiation-halogen exchange reactions to introduce other functional groups at the aromatic ring.
• Research & Development: A valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	2-(Trifluoromethoxy)Bromobenzene
CAS No.	64115-88-4
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	1-Bromo-2-(trifluoromethoxy)benzene; o-Bromophenyl trifluoromethyl ether; 2-Bromophenyl trifluoromethyl ether; (2-Bromophenoxy)trifluoromethane; Bromobenzene, 2-(trifluoromethoxy)-; Benzene, 1-bromo-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Bromobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.