Description

10,11-Dihydro-2-[(4-Methyl-1-Piperazinyl)Methyl]-5H-Dibenz[B,F]Azepine CAS NO 64097-57-0 is a high-purity pharmaceutical intermediate and research chemical characterized by its dibenzazepine core structure. This compound is of significant value for its role in the synthesis and development of advanced active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of tricyclic antidepressant and antipsychotic drug candidates.
• Neurological Research: Used in preclinical studies to investigate mechanisms related to neurotransmitter reuptake inhibition.
• Chemical Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in API manufacturing.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex dibenzazepine derivatives.
• Academic Research: Utilized in universities and R&D labs for studying structure-activity relationships (SAR) in medicinal chemistry projects.

Basic Information

Product Name	10,11-Dihydro-2-[(4-Methyl-1-Piperazinyl)Methyl]-5H-Dibenz[B,F]Azepine
CAS No.	64097-57-0
Molecular Formula	C20H25N3
Molecular Weight	307.43 g/mol
Synonyms	2-[(4-Methylpiperazin-1-yl)methyl]-10,11-dihydro-5H-dibenzo[b,f]azepine; Desmethylclozapine; Norclozapine; Clozapine N-Desmethyl Metabolite; 1-Methyl-4-[(10,11-dihydro-5H-dibenzo[b,f]azepin-2-yl)methyl]piperazine; 64097-57-0; DBZP derivative
EINECS	Contact for details

Quality Control

Our 10,11-Dihydro-2-[(4-Methyl-1-Piperazinyl)Methyl]-5H-Dibenz[B,F]Azepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.