Description

(Phe11)-Neurotensin is a synthetic peptide analog of the endogenous tridecapeptide neurotensin, characterized by the substitution of phenylalanine at the 11th position. This modification is significant for research into the structure-activity relationships of neurotensin and its interaction with NTS1 and NTS2 receptors. It is a critical tool for biochemical and pharmacological research, particularly in neuroscience, oncology, and metabolic studies. This high-purity peptide is essential for academic institutions, pharmaceutical R&D laboratories, and biotechnology companies conducting advanced peptide research.

Application

• Neuroscience Research: Used as a selective ligand to study the role of neurotensin receptors (NTS1/NTS2) in the central nervous system, including neurotransmission, pain modulation, and behaviors like locomotion and reward.
• Cancer Research: Investigated for its effects on cancer cell proliferation, migration, and apoptosis, given neurotensin's role as a growth factor in various cancers (e.g., pancreatic, prostate, colon).
• Metabolic Studies: Employed in research on gut-brain axis signaling, lipid metabolism, and insulin secretion due to neurotensin's physiological functions in the gastrointestinal tract.
• Receptor Binding Assays: Serves as a reference standard or competitor in radioligand binding and fluorescence polarization assays to characterize receptor affinity and density.
• Drug Discovery & Development: Acts as a key intermediate or pharmacological tool in the design and screening of novel neurotensin receptor agonists or antagonists for therapeutic applications.
• Biochemical Standard: Used for method development and calibration in analytical techniques such as HPLC and Mass Spectrometry within quality control and research settings.

Basic Information

Product Name	(Phe11)-Neurotensin
CAS No.	64088-65-9
Molecular Formula	C₈₀H₁₂₂N₂₄O₂₁
Molecular Weight	1796.0 g/mol
Synonyms	Neurotensin (8-13), Phe(11)-substituted; [Phe11]Neurotensin; H-Arg-Arg-Pro-Tyr-Ile-Leu-OH (Phe11 analog); Neurotensin fragment 8-13 (Phe11); NT (8-13), Phe11; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Phe-Leu-OH (Phe11); Neurotensin-related peptide (Phe11)
EINECS	Contact for details

Quality Control

Our (Phe11)-Neurotensin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data from multiple orthogonal methods, including HPLC for purity and MS for identity confirmation. Our quality commitment supports research requiring high-purity, well-characterized peptide standards for reliable and reproducible experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area percent at 214 nm)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.