Description

[D-Trp11]-Neurotensin is a synthetic, biologically active peptide analog of the endogenous tridecapeptide neurotensin. This modified sequence, where the L-tryptophan at position 11 is replaced with its D-isomer, offers enhanced metabolic stability and altered receptor interaction profiles compared to the native peptide. It serves as a critical research tool in neuroscience, endocrinology, and pharmacology for studying neurotensin receptor signaling, peptide hormone function, and potential therapeutic pathways. Key users include pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neurobiology and drug discovery.

Application

• Neuroscience Research: Used as a selective ligand to study the structure, function, and distribution of neurotensin receptors (NTS1 and NTS2) in the central nervous system.
• Pharmacological Studies: Employed in in vitro and in vivo assays to investigate neurotensin-mediated effects such as analgesia, hypothermia, and modulation of dopamine transmission.
• Drug Discovery & Development: Serves as a reference standard and a lead compound for designing novel neurotensin analogs with potential therapeutic applications in psychiatric disorders, pain management, and cancer.
• Biochemical Assays: Utilized in receptor binding studies, signal transduction experiments, and functional cellular assays to elucidate downstream signaling pathways.
• Academic & Institutional Research: A fundamental reagent for basic science exploring the role of neurotensin in gastrointestinal motility, pancreatic secretion, and cell proliferation.

Basic Information

Product Name	[D-Trp11]-Neurotensin
CAS No.	64088-62-6
Molecular Formula	C₇₈H₁₂₁N₂₁O₂₀
Molecular Weight	1673.9 g/mol
Synonyms	D-Tryptophan-11-neurotensin; Neurotensin (D-Trp-11); pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-D-Trp-Leu; Neurotensin, 11-D-tryptophan-; NT (D-Trp11); H-pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-D-Trp-Leu-OH; D-Trp(11)-Neurotensin
EINECS	Contact for details

Quality Control

Every batch of [D-Trp11]-Neurotensin is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous purity and identity verification using advanced analytical techniques including HPLC, MS, and amino acid analysis to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA), detailing purity, peptide content, and analytical results, is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.