Description

N,N'-Pentamethylenebis(Iodoacetamide) is a specialized bifunctional alkylating agent featuring two reactive iodoacetamide groups linked by a pentamethylene spacer. This molecular architecture makes it a valuable cross-linking reagent and a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought by researchers and process chemists in the life sciences and specialty chemical sectors for its ability to introduce specific functional handles or create stable covalent linkages under controlled conditions.

Application

• Bioconjugation and Protein Modification: Used to cross-link peptides, proteins, or enzymes to other biomolecules or solid supports via cysteine thiol groups.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of targeted therapeutic agents, including enzyme inhibitors and antibody-drug conjugates (ADCs).
• Polymer Chemistry: Acts as a functional monomer or cross-linker for creating specialty polymers with tailored properties for research applications.
• Chemical Probe Synthesis: Utilized to develop activity-based probes for studying enzyme function and mechanism in biochemical research.
• Material Science: Employed in the surface functionalization of nanomaterials and the development of novel organic frameworks.
• Linker Chemistry: Functions as a versatile heterobifunctional linker in the design of complex molecular architectures for drug discovery platforms.

Basic Information

Product Name	N,N'-Pentamethylenebis(Iodoacetamide)
CAS No.	64058-91-9
Molecular Formula	C9H14I2N2O2
Molecular Weight	435.03 g/mol
Synonyms	1,5-Di(iodoacetamido)pentane; Pentamethylenebis(iodoacetamide); N,N'-(1,5-Pentanediyl)bis[2-iodoacetamide]; 1,1'-(Pentane-1,5-diyl)bis(2-iodoethan-1-imine); Bis(iodoacetamido)pentane; Iodoacetamide pentamethylene dimer
EINECS	Contact for details

Quality Control

Our N,N'-Pentamethylenebis(Iodoacetamide) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced techniques including HPLC, NMR, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if possible and opened only in a dry environment to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	< 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.