Description

Cardiolipin CAS NO 64043-42-1 is a unique dimeric phospholipid, primarily found in the inner mitochondrial membrane of eukaryotic cells. Its structural role and ability to interact with key mitochondrial proteins make it a critical component for maintaining membrane integrity and supporting essential bioenergetic functions. This high-purity biochemical is indispensable for research in mitochondrial biology, apoptosis studies, and the development of diagnostic assays for autoimmune diseases like anti-phospholipid syndrome.

Application

• Biochemical Research & Assay Development: Essential for studying mitochondrial function, membrane dynamics, and apoptosis signaling pathways.
• Diagnostic Reagent Manufacturing: Used as a key antigen in enzyme-linked immunosorbent assays (ELISA) for the detection of anti-cardiolipin antibodies, critical for diagnosing anti-phospholipid syndrome and other autoimmune disorders.
• Liposome & Drug Delivery System Formulation: Serves as a component in model membrane systems and specialized liposomes for targeted drug delivery research.
• Reference Standard: Employed as a high-purity analytical standard in pharmaceutical quality control and academic research laboratories.
• Enzyme Activity Studies: Used as a substrate or co-factor in studies involving phospholipases and other lipid-metabolizing enzymes.

Basic Information

Product Name	Cardiolipin
CAS No.	64043-42-1
Molecular Formula	C81H156O17P2 (for tetra-linoleoyl cardiolipin, a common form)
Molecular Weight	~1450.0 g/mol (varies by fatty acid composition)
Synonyms	1,3-Bis(sn-3'-phosphatidyl)-sn-glycerol; Diphosphatidylglycerol; Bis(1,2-diacyl-sn-glycero-3-phospho)-1',3'-sn-glycerol; Bovine Heart Cardiolipin; CL; Anti-Cardiolipin Antigen; Mitochondrial Phospholipid
EINECS	Contact for details

Quality Control

Our Cardiolipin is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by HPLC/TLC, fatty acid profile analysis, and functional validation in relevant assay systems. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is easily oxidized; for optimal preservation, store under an inert atmosphere (e.g., argon or nitrogen) after opening. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Yellowish viscous liquid or solid
Identification (TLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Typical 97-99%)
Solubility	Soluble in chloroform, ethanol; forms liposomes in aqueous buffer
Fatty Acid Composition	Predominantly linoleic acid (C18:2) for bovine heart source; other compositions available
Peroxide Value	< 5 mEq/kg
Water Content (KF)	< 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.