Description

4,4-Difluoro-2-Butanol is a versatile fluorinated alcohol building block of significant interest in advanced organic synthesis. Its value lies in the strategic introduction of fluorine atoms and a hydroxyl group, enabling precise modulation of molecular properties such as lipophilicity, metabolic stability, and binding affinity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors, serving as a key intermediate for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical synthon for constructing fluorinated active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where fluorine incorporation enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display technologies, improving performance and stability.
• Polymer Modification: Employed to introduce fluorine into polymer backbones or side chains, imparting valuable properties like chemical resistance and low surface energy.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution, esterification, and etherification reactions to create complex, value-added fluorinated molecules.
• Surface Active Agents: Acts as a feedstock for synthesizing fluorinated surfactants and coatings with superior wetting and leveling characteristics.

Basic Information

Product Name	4,4-Difluoro-2-Butanol
CAS No.	64037-40-7
Molecular Formula	C₄H₈F₂O
Molecular Weight	110.10 g/mol
Synonyms	2-Butanol, 4,4-difluoro-; 4,4-Difluorobutan-2-ol; 1,1-Difluoro-3-hydroxybutane; 4,4-Difluoro-2-hydroxybutane; DFB
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-2-Butanol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and oxidizing agents. The product is compatible with common organic solvents but should be stored separately from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	1.15 - 1.25
Refractive Index (20°C)	1.380 - 1.390

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.