Description

12-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-3-Dodecyn-1-Ol is a specialized organic intermediate featuring both a terminal alkyne and a protected hydroxyl group, making it a versatile building block for complex organic synthesis. Its primary value lies in its role as a key precursor for the construction of long-chain molecules, natural product analogs, and advanced materials. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for coupling reactions and molecular scaffolding.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring long aliphatic chains with specific functionalization.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and plant growth regulators where its alkyne moiety enables click chemistry and other modular assembly strategies.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers, dendrimers, and liquid crystals with tailored properties.
• Organic Synthesis & Catalysis: Employed in academic and industrial R&D for Sonogashira coupling, Huisgen cycloaddition (click chemistry), and other metal-catalyzed reactions to create complex molecular architectures.
• Bioconjugation Probe Development: Utilized for labeling biomolecules (proteins, peptides, nucleic acids) due to the reactivity of the alkyne group with azides, facilitating studies in chemical biology and diagnostics.

Basic Information

Item	Details
Product Name	12-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-3-Dodecyn-1-Ol
CAS No.	64031-52-3
Molecular Formula	C₁₇H₃₀O₃
Molecular Weight	282.42 g/mol
Synonyms	3-Dodecyn-1-ol, 12-[(tetrahydro-2H-pyran-2-yl)oxy]-; 12-(Tetrahydro-2H-pyran-2-yloxy)-3-dodecyn-1-ol; THP-protected 12-hydroxy-3-dodecyn-1-ol; 12-(Tetrahydropyran-2-yloxy)dodec-3-yn-1-ol; Propargylic alcohol THP ether derivative; Long-chain alkyne alcohol THP ether; Building block 64031-52-3
EINECS	Contact for details

Quality Control

Our 12-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-3-Dodecyn-1-Ol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.