Description

3,7-Dichloro-5-[3-(4-Methylpiperazino)Propyl]-5H-Dibenz[B,F]Azepine CAS NO 63918-69-4 is a high-purity, complex heterocyclic organic compound featuring a dibenzazepine core substituted with chlorine and a methylpiperazinylpropyl side chain. This molecular architecture makes it a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of central nervous system (CNS) active compounds and other specialized active pharmaceutical ingredients (APIs).

Application

This specialized intermediate is designed for high-value synthesis in regulated industries. Its primary applications include:

• Pharmaceutical Intermediate: Serving as a key building block in the multi-step synthesis of novel psychotropic and neuroactive drug candidates.
• Research & Development: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities targeting CNS receptors.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Fine Chemical Synthesis: Employed in the production of complex, high-value specialty chemicals for advanced material science and agrochemical research.

Basic Information

Product Name	3,7-Dichloro-5-[3-(4-Methylpiperazino)Propyl]-5H-Dibenz[B,F]Azepine
CAS No.	63918-69-4
Molecular Formula	C22H26Cl2N4
Molecular Weight	417.37 g/mol
Synonyms	3,7-Dichloro-5-[3-(4-methyl-1-piperazinyl)propyl]-5H-dibenzo[b,f]azepine; 5-[3-(4-Methylpiperazino)propyl]-3,7-dichloro-5H-dibenz[b,f]azepine; Loxapine Impurity; Loxapine Related Compound; Dibenzo[b,f][1,4]oxazepine derivative; 63918-69-4; Loxapine intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment. We support compliance with ICH guidelines and can provide materials suitable for use in regulated pharmaceutical development under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.