Description

Dipyridamole Mono-o-B-D-Glucuronide is a key glucuronide metabolite of the antiplatelet and vasodilator drug, dipyridamole. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in bioanalytical method development, metabolite identification, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of dipyridamole and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, bioavailability, and clearance mechanisms of dipyridamole.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS assays for clinical and preclinical studies.
• Impurity Profiling: Employed as an impurity marker in the quality control of dipyridamole active pharmaceutical ingredient (API) to ensure product purity and safety.
• Toxicology and Safety Assessment: Aids in understanding the safety profile and potential toxicity of dipyridamole metabolites.
• Regulatory Submissions: Provides critical data to support Investigational New Drug (IND) and New Drug Application (NDA) filings with regulatory bodies like the FDA and EMA.

Basic Information

Product Name	Dipyridamole Mono-o-B-D-Glucuronide
CAS No.	63912-02-7
Molecular Formula	C30H38N8O11
Molecular Weight	662.67 g/mol
Synonyms	Dipyridamole Glucuronide; Dipyridamole O-Glucuronide; 2-[[4-[(4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-2-yl)amino]phenyl]amino]-2-oxoethyl β-D-Glucopyranosiduronic Acid; Persantin Glucuronide; Dipyridamole Monoglucuronide; Dipyridamole-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Dipyridamole Mono-o-B-D-Glucuronide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.