Description

Dacarbazine Related Compound B (2-Azahypoxanthine) is a high-purity analytical reference standard essential for pharmaceutical research and quality control. This compound is critical for ensuring the accuracy and reliability of analytical methods used in the development and manufacturing of oncology drugs. It is primarily utilized by research scientists and quality assurance professionals in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for impurity profiling, method validation, and stability studies.

Application

• Pharmaceutical Impurity Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of process-related impurities and degradation products in Dacarbazine API and finished drug products.
• Analytical Method Development & Validation: Serves as a critical component in developing and validating High-Performance Liquid Chromatography (HPLC) and Ultra-Performance Liquid Chromatography (UPLC) methods for purity assays.
• Stability Indicating Studies: Employed in forced degradation and long-term stability studies to monitor the formation of specific impurities in drug formulations under various stress conditions.
• Quality Control (QC) Testing: Provides an external standard for routine QC testing in pharmaceutical manufacturing to ensure batch-to-batch consistency and compliance with regulatory specifications (e.g., ICH Q3A/B).
• Pharmacological Research: Used in metabolic and pharmacokinetic studies to understand the degradation pathways and biological fate of Dacarbazine and related compounds.

Basic Information

Product Name	Dacarbazine Related Compound B (2-Azahypoxanthine)
CAS No.	63907-29-9
Molecular Formula	C₅H₅N₅O
Molecular Weight	151.13 g/mol
Synonyms	2-Azahypoxanthine; 1,5-Dihydro-5-imino-1,2,3-triazolo[4,5-d]pyrimidin-7(6H)-one; 5-Amino-1H-v-triazolo[4,5-d]pyrimidin-7-ol; Dacarbazine Impurity B; DTIC Impurity B; 5-Imino-1,2,3-triazolo[4,5-d]pyrimidin-7-ol
EINECS	Contact for details

Quality Control

Every batch of Dacarbazine Related Compound B is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with high-grade reference standard specifications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.