Description

(S)-8-Hydroxy Warfarin CAS NO 63740-82-9 is a high-purity, stereochemically defined metabolite of the anticoagulant drug warfarin. This compound is of critical importance as a reference standard and a key intermediate in pharmaceutical research and development. It is essential for scientists and manufacturers in the pharmaceutical, analytical, and life science industries who require precise materials for pharmacokinetic studies, metabolic pathway analysis, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of warfarin metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of warfarin.
• Analytical Method Development: Serves as a key component in developing and validating robust analytical methods for clinical and forensic toxicology.
• Drug Impurity Profiling: Employed as an impurity standard to monitor and control the quality of warfarin active pharmaceutical ingredient (API) during manufacturing.
• Biochemical Research: Used in enzymatic studies to understand the structure-activity relationships of cytochrome P450 enzymes, particularly CYP2C9.
• Synthetic Intermediate: Acts as a chiral building block for the synthesis of more complex molecules or labeled analogs for tracer studies.

Basic Information

Product Name	(S)-8-Hydroxy Warfarin
CAS No.	63740-82-9
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(S)-8-Hydroxywarfarin; (S)-8-Hydroxy-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 8-Hydroxywarfarin (S-enantiomer); (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-8-hydroxy-2H-chromen-2-one; Warfarin, 8-hydroxy-, (S)-; (S)-8-OH Warfarin; 8-Hydroxy-(S)-Warfarin
EINECS	Contact for details

Quality Control

Our (S)-8-Hydroxy Warfarin is manufactured under strict quality control protocols to ensure high chemical purity and stereochemical integrity, suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identification data. We adhere to relevant industry standards for reference materials, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to moisture and light. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.