Description

7-Hydroxywarfarin is a key hydroxylated metabolite of the anticoagulant drug warfarin. This compound is of significant importance in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It serves as a critical reference standard and intermediate for scientists and manufacturers in the pharmaceutical and analytical chemistry sectors, enabling precise drug metabolism analysis and the development of improved therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis of warfarin and its metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance rates of warfarin in preclinical and clinical research.
• Analytical Method Development: Serves as a critical component in developing and validating robust analytical methods for therapeutic drug monitoring and bioequivalence studies.
• Biochemical Research: Employed in enzymatic studies to understand the activity of cytochrome P450 enzymes, particularly CYP2C9, involved in warfarin metabolism.
• Impurity Profiling: Used to identify and quantify process-related impurities or degradation products in warfarin active pharmaceutical ingredient (API) manufacturing.
• Toxicological Research: Applied in studies assessing the safety profile and potential drug-drug interactions associated with warfarin therapy.

Basic Information

Item	Details
Product Name	7-Hydroxywarfarin
CAS No.	63740-81-8
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	7-Hydroxywarfarin; 7-Hydroxy-3-(α-acetonylbenzyl)-4-hydroxycoumarin; 4-Hydroxy-3-(1-phenyl-2-hydroxy-3-oxobutyl)-2H-chromen-2-one; Warfarin, 7-hydroxy-; 7-OH Warfarin; 7-Hydroxy-3-(α-phenyl-β-acetylethyl)-4-hydroxycoumarin
EINECS	Contact for details

Quality Control

Our 7-Hydroxywarfarin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.