Description

(S)-6-Hydroxy Warfarin is a specific stereoisomer and key metabolite of the anticoagulant drug warfarin. This compound is of significant value in pharmaceutical research and development, particularly for metabolic and pharmacokinetic studies. It serves as a critical reference standard and intermediate for analytical method development and bioanalytical investigations. Target users include pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference materials and fine chemicals.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification of warfarin metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolite Studies: Essential for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of warfarin.
• Analytical Method Development: Serves as a critical component for developing and validating robust analytical methods for drug impurity profiling and bioanalysis.
• Drug-Drug Interaction Research: Utilized in studies examining the impact of other drugs on the CYP450-mediated metabolism of warfarin.
• Biochemical Research: Applied in enzymatic assays to study the activity and inhibition of enzymes like CYP2C9 involved in warfarin metabolism.
• Fine Chemical Synthesis: Acts as a chiral building block or intermediate for the synthesis of more complex molecules in medicinal chemistry.

Basic Information

Product Name	(S)-6-Hydroxy Warfarin
CAS No.	63740-80-7
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(S)-6-Hydroxywarfarin; (S)-6-Hydroxy-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 6-Hydroxywarfarin (S-isomer); Warfarin, 6-hydroxy-, (S)-; (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-6-hydroxy-2H-chromen-2-one; (S)-3-(α-Acetonylbenzyl)-6-hydroxy-4-hydroxycoumarin; 6-OH Warfarin (S-enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-6-Hydroxy Warfarin is manufactured under strict quality control protocols to ensure high chemical purity and stereochemical integrity, suitable for demanding research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, chiral purity, identity confirmation, and impurity profiles. We support compliance with ISO and GMP guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.