Description

(R)-4'-Hydroxy Warfarin is a specific stereoisomer of a key warfarin metabolite, offering a high-purity reference standard for analytical and research applications. This compound is critical for studies involving the stereoselective metabolism, pharmacokinetics, and pharmacodynamics of the anticoagulant drug warfarin. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and academic institutions focused on cardiovascular research and drug metabolism. Its defined stereochemistry makes it an essential tool for precise bioanalytical method development and validation.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of warfarin and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolic Pathway Research: Used to investigate the stereoselective metabolism of warfarin, particularly the role of cytochrome P450 enzymes like CYP2C9.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Essential for developing assays to understand the relationship between drug concentration and anticoagulant effect in preclinical and clinical research.
• Bioanalytical Method Development: A critical component for validating HPLC, LC-MS/MS, and other chromatographic methods intended to separate and quantify warfarin enantiomers and their hydroxylated metabolites.
• Impurity Profiling: Acts as a known impurity or degradation product reference in the quality control of warfarin active pharmaceutical ingredient (API) and finished dosage forms.
• Enzymology Studies: Employed as a substrate or reference compound in studies examining the activity and inhibition of specific drug-metabolizing enzymes.

Basic Information

Product Name	(R)-4'-Hydroxy Warfarin
CAS No.	63740-78-3
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(R)-4'-Hydroxywarfarin; (R)-4'-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; 4'-Hydroxywarfarin (R-enantiomer); (R)-4'-OH-Warfarin; Warfarin, 4'-hydroxy-, (R)-; 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-
EINECS	Contact for details

Quality Control

Our (R)-4'-Hydroxy Warfarin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the results for all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.