Description

(R)-6-Hydroxy Warfarin CAS NO 63740-75-0 is a specific stereoisomer and key metabolite of the widely used anticoagulant drug, warfarin. This compound is of significant value in pharmaceutical research and development, particularly for metabolic pathway studies and the development of analytical standards. It is primarily utilized by research institutions, pharmaceutical companies, and contract testing laboratories engaged in pharmacokinetics, drug metabolism, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quantification and identification of warfarin metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Used to investigate the stereoselective metabolism and clearance pathways of warfarin in preclinical and clinical research.
• Analytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or GC-MS methods for therapeutic drug monitoring and bioequivalence studies.
• Biochemical Research: Employed in studies exploring the structure-activity relationships (SAR) of vitamin K epoxide reductase inhibitors.
• Impurity Profiling: Acts as a known impurity or degradation product standard in the quality control of warfarin active pharmaceutical ingredient (API) manufacturing.
• Toxicology Studies: Utilized in research to understand the metabolic activation and detoxification pathways related to warfarin's efficacy and side effects.

Basic Information

Product Name	(R)-6-Hydroxy Warfarin
CAS No.	63740-75-0
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(R)-6-Hydroxywarfarin; 6-Hydroxywarfarin (R-enantiomer); (R)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 6-Hydroxy derivative; Warfarin, 6-hydroxy-, (R)-; (R)-3-(α-Acetonylbenzyl)-6-hydroxy-4-hydroxycoumarin; 6-OH-Warfarin (R-form)
EINECS	Contact for details

Quality Control

Our (R)-6-Hydroxy Warfarin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet stringent standards for research use. A comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and residual solvent analysis is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC, Area %)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.