Description

1,2-Dipalmitoyl-Sn-Glycero-3-Phospho(Tempo)Choline is a synthetic, spin-labeled phospholipid analog, widely utilized as a crucial molecular probe in biophysical and membrane research. Its core value lies in incorporating a stable nitroxide radical (Tempo) into the phosphatidylcholine headgroup, enabling non-invasive investigation of membrane dynamics, structure, and lipid-protein interactions via Electron Paramagnetic Resonance (EPR) spectroscopy. This compound is essential for researchers and developers in pharmaceutical R&D, academic biochemistry, and advanced material science who require precise tools for studying lipid bilayer properties, drug delivery mechanisms, and membrane fluidity.

Application

• Membrane Biophysics Research: As a spin-label for EPR spectroscopy to study lipid bilayer fluidity, phase transitions, and lateral organization.
• Lipid-Protein Interaction Studies: To probe the interaction dynamics and binding sites of membrane-associated proteins and peptides.
• Model Membrane Systems: A key component in the construction of liposomes and supported lipid bilayers (SLBs) for controlled experiments.
• Antioxidant Activity Studies: Investigating the behavior and localization of nitroxide radicals within lipid membranes to understand antioxidant mechanisms.
• Drug Delivery Vector Characterization: Used to trace and analyze the stability, fusion, and cellular uptake of lipid-based nanoparticle carriers.
• Membrane Permeability Assays: Employed to assess the integrity and permeability of artificial and natural membranes under various conditions.

Basic Information

Product Name	1,2-Dipalmitoyl-Sn-Glycero-3-Phospho(Tempo)Choline
CAS No.	63658-52-6
Molecular Formula	C₄₆H₉₃N₂O₈P
Molecular Weight	845.22 g/mol
Synonyms	DPPC-Tempo; 1,2-Dipalmitoyl-sn-glycero-3-phospho(tempo)choline; Tempo-PC; 16:0 Tempo PC; 1,2-Dihexadecanoyl-sn-glycero-3-phospho(2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl)choline; Spin-labeled phosphatidylcholine; SLPC; Nitroxide-labeled DPPC
EINECS	Contact for details

Quality Control

Our 1,2-Dipalmitoyl-Sn-Glycero-3-Phospho(Tempo)Choline is produced under stringent quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and radical content. We adhere to relevant industry standards for research chemicals, ensuring reliable performance in spectroscopic and biochemical assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (EPR)	Radical content ≥ 90% of theoretical
Solubility	Soluble in chloroform, methanol, ethanol; forms vesicles in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.