Description

Cefotaxime CAS NO 63527-52-6 is a third-generation, broad-spectrum cephalosporin antibiotic belonging to the β-lactam class. It is valued for its high efficacy against a wide range of Gram-positive and Gram-negative bacteria, including many penicillin-resistant strains. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable antibiotics used in hospital and clinical settings to treat serious infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for parenteral administration.
• Hospital Infection Treatment: Used in the management of severe infections such as meningitis, septicemia, pneumonia, and complicated urinary tract infections.
• Surgical Prophylaxis: Employed to prevent post-operative infections in major surgeries.
• Gynecological and Obstetric Infections: Treatment of pelvic inflammatory disease and other serious female reproductive system infections.
• Pediatric and Neonatal Care: Formulated for use in treating serious bacterial infections in children and newborns, where its safety profile is well-established.
• Research & Development: Serves as a reference standard in microbiological research, antibiotic resistance studies, and the development of new combination therapies.

Basic Information

Product Name	Cefotaxime
CAS No.	63527-52-6
Molecular Formula	C16H17N5O7S2
Molecular Weight	455.47 g/mol
Synonyms	Cefotaxime Sodium; Cephotaxime; HR-756; Claforan; Zariviz; Cefotax; Cefajet; (6R,7R)-3-(Acetoxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Cefotaxime is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopoeial standards such as USP, EP, and BP. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing parameters like purity, related substances, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the product should be kept under controlled room temperature (15-25°C) and low humidity conditions. For long-term stability, storage at 2-8°C is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (1% solution)	4.5 - 6.5
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Bacterial Endotoxins	< 0.10 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.