Description

4-Amino-3-Chloro-5-(Trifluoromethyl)Benzoyl Chloride is a high-value, multi-functional aromatic intermediate characterized by its reactive benzoyl chloride group and substituted aniline ring. This compound is essential for synthesizing advanced molecules where the introduction of a trifluoromethyl group is critical for modulating biological activity and physicochemical properties. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of herbicides, fungicides, and novel drug candidates where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its unique halogenated structure to create compounds with specific modes of action and improved environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic applications, including liquid crystal displays and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Acts as an intermediate for producing complex, high-performance dyes and pigments, especially azo dyes, where its amino and chloride functionalities allow for precise color tuning.
• Polymer Modification: Employed to introduce functional side chains into polymers, enhancing properties such as thermal stability, chemical resistance, and surface characteristics for advanced material science applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Amino-3-Chloro-5-(Trifluoromethyl)Benzoyl Chloride
CAS No.	63498-15-7
Molecular Formula	C8H4Cl2F3NO
Molecular Weight	258.03 g/mol
Synonyms	3-Chloro-4-amino-5-(trifluoromethyl)benzoyl chloride; 4-Amino-3-chloro-α,α,α-trifluoro-m-toluoyl chloride; 4-Amino-3-chloro-5-trifluoromethylbenzoyl chloride; 2-Chloro-4-(chlorocarbonyl)-6-(trifluoromethyl)aniline; 2-Chloro-α,α,α-trifluoro-4-aminobenzoyl chloride; Benzoyl chloride, 4-amino-3-chloro-5-(trifluoromethyl)-; m-Toluoyl chloride, 4-amino-3-chloro-α,α,α-trifluoro-
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Chloro-5-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the stringent requirements of our global clientele in regulated industries. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.