Description

Metyrapone n-Oxide is a key pharmaceutical intermediate and metabolite of the enzyme inhibitor metyrapone. This compound is of significant importance in research and development for its role in studying steroidogenesis and cytochrome P450 enzyme activity. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic laboratories engaged in endocrinology research, drug metabolism studies, and the synthesis of specialized diagnostic agents.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of advanced pharmaceutical compounds targeting adrenal function.
• Biochemical Research: Used as a reference standard and tool compound in studies of 11β-hydroxylase inhibition and steroid hormone biosynthesis pathways.
• Metabolite Standard: Serves as an analytical standard (e.g., for HPLC, LC-MS) for the identification and quantification of metyrapone metabolites in pharmacokinetic and bioanalytical studies.
• Endocrinology Diagnostics: Employed in research related to diagnostic tests for adrenal disorders, such as Cushing's syndrome.
• Enzyme Inhibition Studies: A vital reagent for investigating the specificity and mechanism of cytochrome P450 enzymes, particularly CYP11B1.
• Reference Material: Used in quality control laboratories to ensure the purity and identity of metyrapone and related substances.

Basic Information

Product Name	Metyrapone n-Oxide
CAS No.	63473-06-3
Molecular Formula	C14H14N2O2
Molecular Weight	242.27 g/mol
Synonyms	2-Methyl-1,2-di-3-pyridyl-1-propanone N-Oxide; Metyrapone N-Oxide; SU-4885 N-Oxide; Metopirone N-Oxide; 1,2-Di(pyridin-3-yl)-2-methylpropan-1-one 1-Oxide; Metyrapone Oxide; 3,3'-Dimethyl-1,2-di(3-pyridyl)propan-1-one 1-Oxide
EINECS	Contact for details

Quality Control

Our Metyrapone n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.