Description

H-D-Asp(Otbu)-Ome·Hcl is a protected aspartic acid derivative, specifically the hydrochloride salt of H-Asp(OtBu)-OMe, which serves as a crucial chiral building block in organic synthesis. This compound matters for its role in facilitating the controlled synthesis of complex peptides and peptidomimetics, where the tert-butyl and methyl ester protecting groups offer orthogonal deprotection strategies. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of aspartic acid into peptide chains.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in designing inhibitors for aspartic proteases.
• Bioconjugation & Labeling: The protected carboxylic acid group allows for selective modification and conjugation in bioconjugate chemistry.
• Chemical Biology Research: Employed in studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	H-D-Asp(Otbu)-Ome·Hcl
CAS No.	63329-02-2
Molecular Formula	C9H18ClNO4
Molecular Weight	239.70 g/mol
Synonyms	H-D-Asp(OtBu)-OMe hydrochloride; (R)-2-((tert-Butoxycarbonyl)amino)succinic acid 4-methyl ester hydrochloride; D-Aspartic acid, β-(tert-butyl ester), α-methyl ester, hydrochloride; Methyl D-aspartate β-tert-butyl ester hydrochloride; Boc-D-Asp(OtBu)-OMe·HCl (common error/related); Aspartic acid derivative D-form; Fmoc-D-Asp(OtBu)-OH precursor
EINECS	Contact for details

Quality Control

Our H-D-Asp(Otbu)-Ome·Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.